Familial adenomatous poliposis is autosomal, predominantly inherited, premalignant disease, which is caused by a mutation in adenomatous poliposis coli gene in chromosome 5q21. Intestinal transplantation is an evolving procedure and has become a
lifesaving procedure for pediatrics and adults with intestinal failure who cannot be managed by conventional therapies. Long-term outcome and cost effectiveness continue to improve and will be comparable to those of total parenteral nutrition.
The
short
gut syndrome is the most common indication. Pancreas transplantation, as a solid organ, vascularized graft, has improved the quality of life for diabetic patients by establishing an insulin-independent, constant normoglycemic state and is a
well-established treatment for patients with insulin-dependent diabetes. The beneficial effect is the maintenance of normoglycemia and possibly the reversal of diabetic complications, such as vasculopathy, neuropathy, and nephropathy. We report a
case
of pancreas-intestinal transplantation in a familial adenomatous polyposis patient along with a review of the literature.
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